What is a good bike route from Boston to San Diego?

A couple of friends and I want to ride a bike from Boston to San Diego. Any advice on certain routes, places to stay, or details, random things to keep in mind? We loveee to ride a bike, but have no experience doing any trip really great.

http://bikeacrossamerica.org/ best site out there for planning a big trip. forums, routes, examples, etc.

2008 Rough Riding (cycling) Nate Harrison Grade on Mt. Palomar in northern San Diego County